解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The downregulation of farnesoid X receptor (FXR; gene name, nuclear receptor subfamily 1 group h member 4), an enteric nuclear bile acid receptor, has been reported in colorectal carcinoma (CRC), and FXR expression has been inversely correlated with CRC stage and clinical outcome. FXR knockdown in chronic colitis mous...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11545
更新日期:2020-07-01 00:00:00
abstract::The transfer and development of chronic hepatitis B virus (HBV) infection is associated with the T cell immune response, therefore investigating the key regulators of cell immune response is needed to improve chronic HBV treatment. Blood samples from patients with chronic HBV infection were used to confirm the correla...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11534
更新日期:2020-07-01 00:00:00
abstract::Cytokine-induced killer (CIK) cells are a group of heterogeneous immune cells which can be isolated from human peripheral blood mononuclear cells and have demonstrated therapeutic benefit both in hematologic malignancies and solid tumors, including colorectal cancer. However, poor tumor-targeted migration has limited ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11539
更新日期:2020-07-01 00:00:00
abstract::Evaluation of carcinogenic substances from the environment is a challenge for scientists. Recently, a novel approach based on 10 key characteristics of human carcinogens classified by the International Agency for Research on Cancer (IARC) has emerged. Carcinogenesis depends on different mechanisms and factors, includi...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2020.11566
更新日期:2020-07-01 00:00:00
abstract::Clear cell renal cell carcinoma (ccRCC) exhibits the highest mortality among all urological malignancies. The investigation of the potential disease progression markers can improve ccRCC diagnosis and treatment. Gene associated with retinoid-interferon-induced mortality-19 (GRIM-19) is involved in carcinogenesis and c...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11498
更新日期:2020-06-01 00:00:00
abstract::Expression of long non-coding RNA SNHG7 (lncRNA-SNHG7) and its clinical significance in hepatocellular carcinoma (HCC) were explored. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression level of lncRNA-SNHG7 in cancer tissues. Kaplan-Meier curves and multivariate Cox proportion...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11490
更新日期:2020-06-01 00:00:00
abstract::Human four-and-a-half LIM domains protein 1 (FHL1) is a member of the FHL protein family, which serves an important role in multiple cellular events by interacting with transcription factors using its cysteine-rich zinc finger motifs. A previous study indicated that FHL1 was downregulated in several types of human can...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11476
更新日期:2020-06-01 00:00:00
abstract::The aim of the present study was to assess the expression of microRNA-146a (miR-146a) in human lung adenocarcinoma cells, its effect on cellular behaviors, and the underlying molecular mechanisms. Reverse transcription-quantitative PCR (RT-qPCR) was used to measure miR-146a expression in the human normal lung epitheli...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11474
更新日期:2020-06-01 00:00:00
abstract::Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) are an approved first-line therapy against unresectable or advanced non-small cell lung cancer (NSCLC) harboring EGFR gene activating mutations. However, the majority of tumors develop acquired resistance against EGFR-TKIs and some tumors exhibi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11524
更新日期:2020-06-01 00:00:00
abstract::Recently, a number of microRNAs (miRNAs) have been reported to play different roles in human cancers, including colorectal cancer (CRC). However, the specific role of miR-758 has not been clarified in CRC. Therefore, the aim of the present study was to explore the role of miR-758 in CRC. RT-qPCR and western blot analy...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11516
更新日期:2020-06-01 00:00:00
abstract::Nucleobindin 2 (NUCB-2) is a multifunctional protein that contains several functional domains and is associated with a wide variety of biological processes, such as food intake and energy homeostasis. NUCB-2 has been demonstrated to be associated with worse malignant outcomes and cell migration in breast and prostate ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11526
更新日期:2020-06-01 00:00:00
abstract::Metastasis remains a notable issue in patients with newly diagnosed colorectal carcinomas (CRC). Although anti-angiogenic therapies target metastatic diseases, hypoxia-inducible factor-1 α (HIF-1α) and vascular endothelial growth factor (VEGF) status are routinely evaluated in primary tumors as metastatic sites are in...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11450
更新日期:2020-05-01 00:00:00
abstract::Cisplatin resistance has been a major factor limiting its clinical use as a chemotherapy drug. The present study aimed to investigate whether SET and MYND domain-containing protein 3 (SMYD3), a histone methyltransferase closely associated with tumors can affect the sensitivity of tumors to cisplatin chemotherapy. Real...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11465
更新日期:2020-05-01 00:00:00
abstract::A gallbladder neuroendocrine neoplasm (GB-NEN) is a unique heterogeneous neoplasm, originating from neuroendocrine cells and able to secrete peptides as its neurotransmitter. Among all the neuroendocrine tumors (NETs), the GB-NEN prevalence is 0.5%, which accounts for ~2.1% of all gallbladder tumors. The current study...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2020.11461
更新日期:2020-05-01 00:00:00
abstract::[This corrects the article DOI: 10.3892/ol.2019.10030.]. ...
journal_title:Oncology letters
pub_type: 已发布勘误
doi:10.3892/ol.2020.11409
更新日期:2020-04-01 00:00:00
abstract::Induction of apoptosis in human cancer cells by Sasa quelpaertensis Nakai has been considered to be a potential therapeutic target for cancer treatment; however, the underlying mechanisms of action are not well understood. The present study investigated the role of nitric oxide (NO•) and inhibitors of apoptosis (IAPs)...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11379
更新日期:2020-04-01 00:00:00
abstract::Effects of Rapamycin on the proliferation and apoptosis of retinoblastoma cells through the phosphatidylinositol 3-hydroxy kinase (PI3K)/protein kinase B (AKT) signaling pathway were studied. The retinoblastoma Y79 cells were selected and divided into negative control group (NC group), 0.2 µM Rapamycin group and 0.4 µ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11363
更新日期:2020-04-01 00:00:00
abstract::Hepatitis B virus × protein (HBx) serves an important role in the pathogenesis of the hepatitis B virus infection. Previous studies have reported that the interaction between HBx and hepatocyte mitochondria is an important factor leading to liver cell injury and apoptosis, ultimately inducing the formation of liver ca...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11404
更新日期:2020-04-01 00:00:00
abstract::Ubiquitin-like modifier-activating enzyme 7 (UBA7) is a specific E1-like ubiquitin-activating enzyme involved in interferon-stimulated gene 15 (ISG15) conjugation. UBA7 expression has been reported to be notably decreased in lung cancer. The present study aimed to investigate the changes in UBA7 expression in breast c...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11406
更新日期:2020-04-01 00:00:00
abstract::A standard treatment for patients with early-stage non-small cell lung cancer (NSCLC) who undergo surgery, and subsequently develop local failure or intrathoracic oligo-recurrence, has not yet been established. The present study aimed to assess the feasibility of stereotactic body radiotherapy (SBRT) for this subgroup...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11407
更新日期:2020-04-01 00:00:00
abstract::The current study investigated the efficacy of podoplanin expression in tumor budding cells as a predictor of neck lymph node metastasis (NLM) in patients with tongue squamous cell carcinoma (SCC) of low tumor budding grade (TBG). A total of 99 patients with early T-stage tongue SCC of any clinical N status who receiv...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11358
更新日期:2020-04-01 00:00:00
abstract::[This corrects the article DOI: 10.3892/ol.2012.934.]. ...
journal_title:Oncology letters
pub_type: 已发布勘误
doi:10.3892/ol.2020.11421
更新日期:2020-04-01 00:00:00
abstract::Portal vein tumor thrombus (PVTT) promotes distant metastasis of hepatocellular carcinoma (HCC), which increases the mortality of patients with HCC and PVTT. The aim of the present study was to develop an early risk warning system for distant metastasis of hepatitis B virus (HBV)-associated primary HCC (HBV-HCC) with ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11423
更新日期:2020-04-01 00:00:00
abstract::Cholangiocarcinoma (CCA) is a primary malignancy, which is often diagnosed as locally advanced or metastatic. Previous studies have revealed genomic characteristics of CCA in Western patients, however comprehensive genomic features of CCA in Chinese patients have not been well understood. To explore the specific genom...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11429
更新日期:2020-04-01 00:00:00
abstract::The lack of hormone receptors in triple negative breast cancer (TNBC) is associated with the inefficacy of anti-estrogen chemotherapies, leaving fewer options for patient treatment and higher mortality rates. Additionally, as with numerous types of inflammatory breast cancer, infiltration of tumor associated macrophag...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11327
更新日期:2020-03-01 00:00:00
abstract::Dysregulated expression of long non-coding RNAs has been determined to be important in cancer development; however, their role in tongue squamous cell carcinoma (TSCC) progression and carcinogenesis, to the best of our knowledge, is yet to be elucidated. The present study revealed that long intergenic non-coding RNA 0...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11293
更新日期:2020-03-01 00:00:00
abstract::Lung cancer causes over 1.6 million mortalities worldwide annually. MicroRNAs (miRs) are involved in various types of cancer-associated processes. The present study investigated the possible mechanism of miR-107 in the development of lung cancer in order to identify novel targets for clinical treatment. The expression...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11248
更新日期:2020-03-01 00:00:00
abstract::A disintegrin and metalloproteinase 9 (ADAM9) is a member of the transmembrane ADAM family. It is expressed in different types of solid cancer and promotes tumor invasiveness. To the best of our knowledge, the present study was the first to examine ADAM9 expression in vestibular schwannomas (VS) from patients with and...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11299
更新日期:2020-03-01 00:00:00
abstract::Fatty acid-binding protein 5 (FABP5), which participates in mediating the biological properties of tumor cells, has been recognized in several neoplasms. The present study aims to investigate FABP5 transcriptional expression profiles, reveal its underlying biological interaction networks and define its prognostic valu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11301
更新日期:2020-03-01 00:00:00
abstract::The underlying molecular mechanisms of pancreatic neuroendocrine tumor (pNET) development have not yet been clearly identified. The present study revealed that thrombospondin 2 (THBS2) was downregulated in pNET tissues and cells. Forced expression of THBS2 inhibited the proliferation and migration of pNET cells in vit...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11273
更新日期:2020-03-01 00:00:00
abstract::Correlation of APOBEC3G expression with liver function indexes of patients with chronic hepatitis B and its expression in chronic hepatitis B, liver cirrhosis and liver cancer were investigated to evaluated the significance of APOBEC3G. Fifty-eight patients with chronic hepatitis B were selected, including 20 cases of...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11257
更新日期:2020-03-01 00:00:00
abstract::The chemokine CXCL10 and its receptor CXCR3 have been demonstrated to be implicated in cancer cell proliferation and metastasis. CXCR3 has three splice variants: CXCR3A, CXCR3B and CXCR3-alt. CXCR3A and B serve multiple roles in the growth and invasiveness of a number of cancer types. However, the roles of CXCR3 isofo...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11326
更新日期:2020-03-01 00:00:00
abstract::The scavenger receptor stabilin-1 has been reported to be expressed by tumor-associated macrophages (TAMs) and to facilitate tumor growth and metastasis in mouse models of breast carcinoma and melanoma. However, to the best of our knowledge, its expression and association with prognosis in human gastric cancer has not...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11310
更新日期:2020-03-01 00:00:00
abstract::The Klotho (KL) gene was first identified as a potent aging suppressor. The KL family currently comprises of three proteins: α-Klotho (KLA), β-Klotho (KLB), and γ-Klotho (KLG). Many studies have shown that KLA and KLB participate in tumor progression or suppression, depending on the type of cancer; however, the relati...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11308
更新日期:2020-03-01 00:00:00
abstract::A common method to distinguish large cell neuroendocrine carcinoma (LCNEC) from non-neuroendocrine large cell carcinoma (non-NE LCC) is from using specific immunohistochemistry markers, such as CgA, Syn, CD56 and Napsin A, however, the results remain controversial using these markers. Secretagogin (SCGN) is a newly di...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11336
更新日期:2020-03-01 00:00:00
abstract::The clinical decisions made when treating patients with metastatic cancer require knowledge of the current tumor extent and response to therapy. For the majority of solid tumors, a response assessment, which is based on imaging, is used to guide these decisions. However, measuring serum protein biomarkers (i.e. tumor ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11192
更新日期:2020-02-01 00:00:00
abstract::As a member of the tripartite motif family, tripartite motif-containing protein 59 (TRIM59) serves as an E3 ubiquitin ligase in various cellular processes, including intracellular signaling, development, apoptosis, protein quality control, innate immunity, autophagy and carcinogenesis. The present study aimed to inves...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11199
更新日期:2020-02-01 00:00:00
abstract::Head and neck squamous cell carcinoma (HNSCC) is the sixth most frequent malignancy with a 5-year survival rate of 54%. Therefore, disease management improvement is required. The present study aimed to assess the role of caveolin-1 (Cav-1) in the metastasis of head and neck tumor cells. Short hairpin RNA was used to s...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11187
更新日期:2020-02-01 00:00:00
abstract::Lung adenocarcinoma (LUAD) is a common malignancy; however, the majority of its underlying molecular mechanisms remain unknown. In the present study, weighted gene co-expression network analysis was applied to construct gene co-expression networks for the GSE19804 dataset, in order to screen hub genes associated with ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11193
更新日期:2020-02-01 00:00:00
abstract::Pleomorphic adenomas (PAs) of salivary glands are the most frequent entity of solid parotid tumors. Nonetheless, their genetics is not yet well understood. Thus, the current study characterized 14 PAs using a unique combination of cytogenetic, molecular cytogenetic and/or molecular karyotyping based approaches. The cu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11198
更新日期:2020-02-01 00:00:00